Acridone-coumarin dimers

Acridone alkaloids comprise a relatively small group of alkaloids that are found solely in some Rutaceae genera. Some 100 examples of this alkaloid group have been isolated and these include the monomeric acridones and the acridone-coumarin dimers (acrimarines) isolated from Citrus plants some binary alkaloids have recently been isolated and described (Takamura et al, 1995). 

No data is available on the biosynthesis of dimeric acridone alkaloids, which have been found in Rutaceae. Acridone-coumarin/xanthone/Ugnin dimers have also been found in Rutaceae (Table 24.17). The bark of the New Caledonia tree Sarcomelicope megistophylla (Rutaceae) have yielded an intriguing range of... 

Twenty-five acridone-coumarin, eleven acridone-acridone and one acridone-lignan dimeric compounds have been isolated until now from various Citrus, Clycosmis and Atalantia species. 

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