Acids phenylalkyl carboxylic

Numerous tyrosine hydroxylase inhibitors, chiefly of the phenylalkyl carboxylic acid type, have been described [101,128, 138, 139, 200, 257]. One of the most potent inhibitors in vitro, 3-iodotyrosine, proved inactive in man, probably because it is rapidly dehalogenated in vivo [72]. H22/54 has been found to be one of the most effective tyrosine hydroxylase inhibitors with catechol structure [44, 257]. The pyrroloisoxazole CL-65,263 and its derivatives represent a new type of tyrosine hydroxylase inhibitor [89, 243]. They lower blood pressure and cause... 

Alkyl carboxylic acids, as their coenzyme A (CoA) thioesters, are metabolized by oxidation at the (3-xap(3ov to the carboxylic carbon (p-oxidation). This pathway involves the oxidative cleavage of two carbon units at a time (as acetate), beginning at the carboxyl terminus and continuing until no more acetate units can be removed. The reaction is terminated when a branch (e.g., valproic acid) or aromatic group is encountered. The metabolism of even and odd phenylalkyl acids can serve as an example ... 

Wolf, H.P.O. Engel, D.W. (1985) Eur. J. Biochem. 146, 359-363. Decrease of fatty acid oxidation, keto-genesis, and gluconeogenesis in isolated perfused rat liver by phenylalkyl oxirane carboxylate (B 807-27) due to inhibition of CPT-1 (EC 2.3.1.21). 

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