Acid sphingomyelinase-derived

Acid Sphingomyelinase-derived Ceramide Signaling in Apoptosis... 

Heinrich, M., Wickel, M., Schneider-Brachert, W., Sandberg, C., Gahr, J., Schwander, R., Weber, T., Saftig, P., Peters, C., Brunner, J., Kronke, M. and Schutze, S., 1999, Cathepsin D targeted by acid sphingomyelinase-derived ceramide. EMBO J. 18 5252-5263... 

Hamada, M., likubo, K., Ishikawa, Y., Ikeda, A., Umezawa, K., and Nishiyama, S., Biological activities of alpha-mangostin derivatives against acidic sphingomyelinase, Bioorg Med Chem Lett, 13 (2003) 3151-3153. 

The enantioselective synthesis of phosphonothioate (146) and fluoromethylene phosphonate (147) analogues of cyclic phosphatidic acid, the novel antagonists of lysophosphatidic acid receptors, has been presented. Synthesis of difluoromethy-lene analogue of sphingomyelin (148) in optically active form as a new sphingomyelinase inhibitor has been achieved. The synthesis and biological evaluation of 9-(5, 5 -difluoro-5 -phosphonopentyl)guanine derivatives (149), for use as a purine nucleoside phosphorylase inhibitor, has been described. 

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