Acid phosphatase historical

Historically, the protein phosphatases were classified into two groups according to their substrate specificity tyrosine phosphatases and serine/threonine protein phosphatases. The latter are metalloenzymes we will refer to these as metallophospha-tases, a superfamily of enzymes that includes the serine/threonine protein phosphatases, purple acid phosphatases, and other enzymes capable of phosphoryl group transfer reactions such as bacteriophage A protein phosphatase [17, 18]. 

Historically, the difference between acid and alkaline phosphatase rested on the simple observation that enzymes could be separated which had optimal rates in completely different pH ranges. Since addition or... 

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