Acid Chloride to an Anhydride

This mechanism follows the standard pattern of an addition-elimination mechanism, ending with loss of a proton to give the final product. 

Acid chlorides react rapidly with alcohols to give esters in a strongly exothermic reaction. This reaction requires caution to keep the temperature low to avoid dehydration of the alcohol. 

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Key Mechanism 21-1 Addition-Elimination Mechanism of Nucleophilic Acyl Substitution 998 Mechanism 21-2 Conversion of an Acid Chloride to an Anhydride 1001... 

Esterification Using Diazomethane 966 Conversion of an Acid Chloride to an Anhydride 1001 Conversion of an Acid Chloride to an Ester 1001 Conversion of an Acid Chloride to an Amide 1002 Conversion of an Acid Anhydride to an Ester 1002 Conversion of an Acid Anhydride to an Amide 1003 Conversion of an Ester to an Amide (Ammonolysis of an Ester) 1003 Transesterification 1008 Saponification of an Ester 1010 Basic Hydrolysis of an Amide 1012 Acidic Hydrolysis of an Amide 1012... 

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