Acid-base catalysis in enzymes

W.P. Jencks, Structure-Reactivity Correlations and General Acid-Base Catalysis in Enzymic Transacylation Reactions, Cold Spring Harbor Symp. Quant. Biol, 1971, 36, 1. [Pg.69]

Hydrogen transfer is one of the most pervasive and fundamental processes that occur in biological systems. Examples include the prevalent role of acid-base catalysis in enzyme and ribozyme function, the activation of C-H bonds leading to structural transformations among a myriad of carbon-based metabolites, and the transfer of protons across membrane bilayers to generate gradients capable of driving substrate transport and ATP biosynthesis. [Pg.1241]