Aciclovir Theophylline

ACICLOVIR/ VALACICLOVIR BRONCHODILATORS -THEOPHYLLINES t theophylline levels Uncertain Monitor for signs of toxicity and check levels... [Pg.629]

Preliminary evidence su ests that aciclovir can increase the serum levels of theophylline. [Pg.1170]

Prompted by a case of increased theophylline adverse effects in a patient given aciclovir, a study was carried out in 5 healthy subjects who were given single 320-mg doses of theophylline (as 400 mg of aminophylline) before and with the sixth dose of aciclovir 800 mg five times daily for 2 days. The AUC of the theophylline was increased by 45% and its total body clearance was reduced by 30% by the aciclovir. ... [Pg.1170]

Uncertain, but the evidence suggests that aciclovir inhibits the oxidative metabolism of theophylline, resulting in accumulation. ... [Pg.1170]

Evidence appears to be limited to this report. However, be alert for an increase in adverse effects of theophylline (nausea, headache, tremor) if aciclovir is added to established treatment, and consider monitoring levels. More study is needed. [Pg.1170]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...