Achlya Steroid hormones

Bmnt, S.A. J.C. Silver. 1986. Steroid hormone-induced changes in secreted proteins in the filamentous fungus Achlya. Exp. Cell Res. 163 22-34. 

Bmnt, S.A., R. Riehl J.C. Silver. 1990. Steroid hormone regulation of the Achlya ambisexualis 85-kilodalton heat shock protein, a component of the Achlya steroid receptor complex. Mol. Cell. Biol. 10 273-281. 

Antheridiol.—The structure determination of antheridiol (100), the first specifically functioning steroidal sex hormone to be found in the plant kingdom which, when secreted by the female mycelia of the aquatic fungus Achlya bisexualis, initiates sexual reproduction, has been rapidly followed by its synthesis. Aldol condensation of ethyl 3,4-dimethylpent-2-enoate with the aldehyde (96) produced the unsaturated lactone (98) which could be op>ened to the dienic acid (99) with... 

The fungus Achlya (male strain) secretes a hormone oogoniol which causes the female strain to form egg-bearing branches. This hormone is a steroid, with oxygen atoms attached to the 7- and 15-positions, (McMorris etaL, 1975). 

A second hormone, produced by the male hyphae, has been shown to be a mixture of oogoniols 1 and 2 (44 and 45). These steroidal compounds are active at 620 and 460 ng/ml, respectively. Cultures of Achlya ambisexualis produced oogoniols only after treatment with antheridiol. Antheridiol appears to induce the formation of an enzyme necessary for the production of oogoniols (Mascarenhas, 1978 O Day and Horgen, 1981). 

Barksdale, A.W., T.C. McMorris, R. Seshadri, T. Aranchalam, J.A. Edwards, J. Sundeen D.M. Green. 1974. Response of Achlya ambisexualis E87 to the hormone antheiidiol and certain other steroids. J. Gen. Microbiol. 82 295-299. 

McMorris, T.C. R. White. 1977. Biosynthesis of the oogonials, steroidal sex hormones of Achlya the role of fucosterol. Phytochemistry 16 359-362. 

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