AChE inhibitor poisoning acute

Long-acting AChE inhibitors are commonly used as insecticides. Whereas these are less toxic for humans, they still provide a hazard, causing poisoning with both acute and chronic symptoms caused by both muscarinic and nicotinic hyperactivity ("dumbbelss"). 

Therapy for acute poisoning by AChE inhibitors includes administration of M blockers (atropine) and pralidoxime (2-PAM), which helps reactivate AChE. 

Whereas the lime course of recovery from acute poisoning in humans depends on the chemical and the level of exposure, acute cholinergic. signs of intoxication with cholinesterase inhibitors typically abate by 24 hr after treatment in rats. Reactivation of the AChE enzyme is much slower than this time course indicates, suggesting that... 

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