Ach Regulates Its Own Release from Glomus Cells

In explaining the potential interrelationships between ACh and DA in the cat carotid body two assumptions have substantial data supporting them. Namely, ACh can 

Marcel Dekker, Inc. 270 Madison Avenne, New Ycnk, New Yoik 10016 

Stimulate and DA can inhibit cat carotid body neural output. Second, nicotinic, muscarinic, and dopaminergic receptors act in the cat carotid body as they do elsewhere. Thus, exocytotically released ACh and DA should stimulate and inhibit, respectively, postsynaptic neural traffic in the carotid sinus nerve. PresynapticaUy (i.e., on the glomus cells) the presence of the receptors would suggest that—as in other species— they can regulate by positive/negative feedback their own release from the glomus cells and, perhaps, the release of other neurotransmitters. 

Marcel Dekker, bfc. 270 Madison Avenne, NewYoik, NewYoifc 10016 

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