Acetylenic ethers polyfunction

Alkynylation of zinc-copper compounds has been used for the synthesis of polyfunctional acetylenic ethers [84] and for the preparation of building blocks for pharmaceutically active compounds [85]. Whereas cross-coupling between non-activated iodoalkenes and zinc-copper reagents only proceeds at elevated temperatures and in polar solvents such as NMP or DMPU (60 12 h) [86], alkenyl... 

Polyfunctional zinc-copper reagents react efficiently with 1-bromo- or I-iodoaUcynes furnishing functionalized alkynes in good yields. The reaction proceeds at low temperature (—65 °C to —55 °C) and has been applied to the preparation of pheromones (Scheme 9-23 [53]) and polyfunctional acetylenic ethers [54]. 

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