Acetylenes antifungal activity

Many isolated acetylenic compounds have pronounced antifungal activity (and often antibacterial activity), but their inherent instability limits their usefulness for this purpose. One example is the antibiotic mycomycin (12) isolated from a basidiomycete, Nocardia acidophilus (Weiss and Edwards, 1980). 

Varying degrees of vitro antifungal activity have been claimed for a variety of chemical types. Among these are substituted 8-hydroxyquino-lines,J 2 acetylenic con5>oun, 3 2-fluorofatty acids,alkyl phenyl sulfides,aryl thiocyanates,substituted phenylhydrazines and phenyl-pyrazolones methyl-5-(3,3-dimethyl-l-triazeno)imidazole- -carboxylate p-hydroxypropiophenone,50 substituted benzimidazoles,51 2,U-bis(arylamino)-5-methylpyrimidines52 and isothiocyanates.53... 

Acetylenes, few of which are biologically active, have also been isolated from microorganisms and marine organisms, such as the antifungal acetylenic cyclohexene-epoxide derivative asperpentyn isolated from Aspergilus and dactylyne, an acetylenic dibromochloro-ether, isolated from sea hare. Dactylyne was shown to be a very potent inhibitor of drug metabolism... 

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