Acetylcholinesterase inhibition by nerve agents

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Picha, J., Kuca, K., Kivala, M., et al., 2005. New group of monoquaternary reactivators of the acetylcholinesterase inhibited by nerve agents. J. Enzyme Inhib. Med. Chem. 20, 233-237. 

Acetylcholinesterase An enzyme that hydrolyzes the neurotransmitter acetylcholine. The action of this enzyme is inhibited by nerve agents. 

FIGURE 3.4 Mechanism of action of acetylcholinesterase inhibition (A) Structure of AChE (B) normal functioning of AChE (C) inhibition of AChE by nerve agent sarin. (Adapted from Somani et al. )... 

Mercey, G., Verdelet, T., Renou, J., et ah, 2012a. Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. Acc. Chem. Res. 45,... 

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