Acetylcholine receptor binding

Basu N, Stamler CJ, Loua KM, Chan HM. 2005a. An interspecies comparison of mercury inhibition on muscarinic acetylcholine receptor binding in the cerebral cortex and cerebellum. Toxicol Appl Pharmacol 205 71-76. 

Grinevich, V.P., Letchworth, S.R., Lindenberger, K.A. et al. Heterologous expression of human alpha 6 beta 4 beta 3 alpha 5 nicotinic acetylcholine receptors binding properties consistent with their natural expression require quaternary subunit assembly including the alpha 5 subunit. J. Pharmacol. Exp. Then 312 619, 2005. 

F. Liang, H.A. Navarro, P. Abraham, P. Kotian, Y.S. Ding, J.S. Fowler, N.D. Volkow, M.J. Kuhar, F.l. Carroll, Synthesis and nicotinic acetylcholine receptor binding properties of exo-2-(2 -fluoro-5 -pyridinyl)-7-azabicyclo-[2.2.1 (heptane A new positron emission tomography ligand for nicotinic receptors, J. Med. Chem. 40 (1997) 2293-2295. 

Syntheses, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2 -Substituted 5-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Epibatidine-analogues, J. Med. Chem. 

Binding of quinolizidine alkaloids to acetylcholine receptors. Binding was analyzed using radio receptor assays. (From Schmeller, T., et al. 1994. J. Nat. Prod. 57, 1316-1319 with permission). 

Kao, P. N., and Karlin, A., 1986, Acetylcholine receptor binding site contains a disulphide crosslink between adjacent half-cystinyl residues. J. Biol. Chem. 261 808598088. 

DL, Gunther KL, Kim DJ, Kuntzweiler TA, Sullivan JP, Decker 55. MW, Arneric SP. Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent effect of pyridine and azeti- 56. dine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice. Bioorg. Med. Chem. Lett. 1998 8 2797-2802. 

Muscarinic acetylcholine receptor binding the effect of large alcohol moiety... 

SAR of quinuclidine aldoximes muscarinic acetylcholine receptor binding... 

Carroll, F.L. Liang, F. Navarro, H.A. Brieaddy, L.E. Abraham, R Damaj, M.I. Martin, B. R. Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-cxo-2-(2 -substituted 5 -pyridinyl)-7-azabicyclo [2.2.1]heptanes. Epibatidine analogues. J. Med. Chem. 44(13),2229-2237. 

Stiles BG. 1993. Acetylcholine receptor binding characteristics of snake and cone snail venom postsynaptic neurotoxins Further studies with a non-radioactive assay. Toxicon 31 825-834. 

Teeguarden JG, Housand CJ, Smith JN, Hinderliter PM, Gunawan R, Timchalk CA. A multi-route model of nicotine-cotinine pharmacokinetics, pharmacodynamics and brain nicotinic acetylcholine receptor binding in humans. Regal Toxicol Pharmacol 2013 65(l) 12-28. 

Studies Acetylcholine receptor binding and blocking antibodies were positive, as was the anti-striated-muscle antibody. Other immunological parameters were normal, as were thyroid function tests. Repetitive nerve stimulation at low-frequency (3 Hz) showed an 18% decremental response of the compound-motor-unit potential indicating MG (normal is < 11 % decrement). Nerve conduction studies were normal. Computed tomography (with contrast) of the mediastinum revealed a mass, presumably thymoma. 

Carroll FI, Lee JR, Navarro HA, Ma W, Biieaddy LE, Abraham P, Damaj MI, Martin BR (2002) Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2, 3 -disubstituted 5 -pyiidinyl)-7-azabicyclo[2.2.1]heptanes epibatidine analogues a new positron emission tomography ligand for nicotinic receptors. J Med Chem 45(21) 4755 761... 

The antigenic determinant is located at loop B, which is also the acetylcholine receptor-binding region (Kase et al., 1989). 

Endo T., Oya, M., Tamiya, N. and Hayashi, K. (1987) Role of C-terminal tail of long neurotoxins from snake venoms in molecular conformation and acetylcholine receptor binding Protein nuclear magnetic resonance and competition binding studies. Biochemistry 26 4592-4598. 

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