Acetyl-CoA transacylase

After malonyl-CoA synthesis, the remaining steps in fatty acid synthesis occur on fatty acid synthase, which exists as a multienzyme complex. In the initial reactions acetyl-CoA and malonyl-CoA are transferred onto the protein complex by acetyl-CoA transacylase and malonyl-CoA transacylase (step 1 and step 2 in fig. 18.12a). The acceptor for the acetyl and malonyl groups is acyl carrier protein (ACP). ACP also carries all of the intermediates during fatty acid biosynthesis. The prosthetic group that binds these intermediates is... 

Figure 19.13 Biosynthesis of palmitate via fatty acid synthetase. The numbered enzyme activities (steps) are as follows (1) acetyl-CoA transacylase (2) malonyl-coA transacylase (3) /3-ketoacylsynthetase (4) j3-ketoacylreductase (5) /3-hydroxyacyldehydratase (6) enoyl reductase (7) fatty acyltransacylase. (Reproduced by permission from Wakil SJ, Stoops JK, Joshi VC. Fatty acid synthesis and its regulation. Annu Rev Biochem 52 537-579, 1983.)...

---