Acetrizoate

High Osmolality Contrast Media. An important advance in radiopaques came with the synthesis of aminotriiodoben2oic acid and its acetylated derivative, acetrizoic acid [85-36-9] (5) (8,9). Aqueous solutions of sodium acetrizoate possessed the thermal stabiUty so that they could be autoclaved (10) with minimal decomposition. The higher iodine content, ie, 3 atoms/molecule, increased the contrast efficiency, and the clinical safety of acetrizoate was improved over that of the earlier urographic agents. 

Acetic anhydride Acetaminophen Acetazolamide Acetrizoate sodium Acetyl cysteine Acetyl sulfisoxazole Afloqualone... 

C7H4I3NO2 31I9-15-I) see Acetrizoic acid Adipiodone lobenzamic acid lodoxamic acid loglycamic acid lotroxic acid... 

The role of extracellular enzymatic systems in the degradation of triiodinated aromatics compounds was demonstrated by the same authors. Degradation yields between 87% and 93% for diatrizoate, iodipamide, and acetrizoate, and between 68% and 73% for aminotrizoate and aminotriiodoisophthalate were observed in in vitro experiments with extracellular enzyme concentrate of T. versicolor in the... 

Acetrizoate T. versicolor 65% after 14 days 1 metabolite detected ... 

Acetrizoate has a more marked effect in this respect than an equiosmolar solution of diatrizoate. Methylglucamine salts appear to be relatively less vasoactive in the peripheral vessels. All these changes are considerably less marked with low-osmolar media such... 

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