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2-Acetoxymethyl-5-methylpyrazine hydrolysis

Chloromethyl-5-methylpyrazine (242) gave either 2-acetoxymethyl- (243) (AcOK, EtOH, reflux, 6 h 65%) or 2-hydroxymethyl-5-methylpyrazine (224) (AcOK, KHC03, EtOH, reflux, 6 h 74%) 221 the acetoxymethyl intermediate was confirmed as such by alkaline hydrolysis to the product (244) (NaOH, no details 85%).1353... [Pg.184]

Dimethylpyrazine 1-oxide (280) gave 2-acetoxymethyl-3-methylpyrazine (281) (neat Ac20, reflux, 30 min 77%) 1272 the isomeric 2,6-dimethyl-pyrazine 1-oxide gave a separable mixture of 2-acetoxymethyl-6-methylpyrazine (282, R = Ac) and 2-hydroxymethyl-6-methylpyrazine (282, R = H), the latter arising presumably by hydrolysis during the work up (neat Ac20, reflux, 1 h 40 and 12%, respectively).1307... [Pg.236]

See other pages where 2-Acetoxymethyl-5-methylpyrazine hydrolysis is mentioned: [Pg.166]   
See also in sourсe #XX -- [ Pg.185 ]

See also in sourсe #XX -- [ Pg.185 ]



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