2-Acetoxyisobutyryl chloride

Seleiio-cytidine gives the novel 2-cyclo-2-selenocytidine (74) on treatment with 2-acetoxyisobutyryl chloride. 

Of the alterations that involved the sugar and the pyrimidine moieties, one is the anhydro ring formation between the two subunits. Pseudouridine (3) forms three types of anhydro compounds, namely, 4,2 -, 4,3 -, and 4,5 -anhydro derivatives. Treatment of 3 with salicoyl chloride or a-acetoxyisobutyryl chloride gave a mixture of the 4,2 -anhydro derivative 943 together with the 2 -chloro-2 -deoxypseudouridine 944. This mixture... 

Greenberg and Molfatt have confirmed and extended these results, but they used a-acetoxyisobutyryl chloride, which is not chiral, to simplify the reactions. 

The reaction of pseudouridine with a-acetoxyisobutyryl chloride has been reinvestigated, and some of the findings are outlined in Scheme 12. The major product had previously been assigned a ribo... 

N-((Benzyl)oxy)carbonyl)-L-phenylalaninal Phosphorous pentasulfide Vanadium(III) chloride Ethyl chloroacetate a-Acetoxyisobutyryl bromide Thioformamide... 

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