2-Acetoxy methyl-6-methylpyrazine

Amino-3-cyano-5-methylpyrazine 1,4-dioxide (91) refluxed for several minutes with acetic anhydride formed 3-acetamido-2-cyano-5-hydroxy-6-methylpyrazine 1-oxide (92) (24%) (532) and 2-acetoxymethyl-5-methylpyrazine 1,4-dioxide refluxed with acetic anhydride afforded a mixture of2,5-di(acetoxymethyl)pyrazine 1-oxide, with some 2,5-diacetoxymethylpyrazine and a monoxide of 2-acetoxy-methyl-5-methylpyrazine (625). 2-Formylpyrazine hydrate 1,4-dioxide with aqueous sodium hydroxide or bicarbonate at < 37° in an unusual reaction gave 3-carboxy-pyrazine 1-oxide mixed with 5 [Pg.188]

Acetoxy-5-benzyl-6-diacetylamino-3-methylpyrazine (31) gave 6-amino-5-bcnzyl-3-methyl-2( I //)-pyrazinone (32) (neat H2NNH2, 20°C, 13 h 67% note additional IV-deacetylation).883 Also other examples.304 809 960,1565 1575... 

Benzyl-5-methyl-2-pyrazinamine 1-oxide (275) gave 2-acetoxy-5-benzyl-6-di-acetylamino-3-methylpyrazine (276) (Ac20—AcOK, reflux, 10 min 67%).883... 

---