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2-Acetonyl-6-phenylpyrazine

Acetamido-2(l//)-pyrazinethione 3-Acetanudo-20 //)-pyrazinone 2-Acetonyl-5,6-diphenylpyrazine 2-Acetonyl-6-methylpyrazine 2-Acetonyl-3-phenylpyrazine 2-Acetonyl-6-phenylpyrazine 2-Acetonylpyrazine... [Pg.352]

Ring aUylation and propenylation of methylpyrazine has been described (634) acetonylpyrazine with phenyllithium gives 2-acetonyl-6-phenylpyrazine (639) and 2,5-dimethylpyrazine with isopentylUthium gave 3-isopentyl-2,S-dimethylpyrazine (70). Aldehydes and ketones in the presence of a solution of an alkali or alkaline earth metal in liquid ammonia, or a suspension of these metals in other solvents, can be used to alkylate the pyrazine ring in moderate to good yields (614, 640, 641). This alkylation has been successfully applied to alkyl- and dialkyl(amino- and methoxy)pyrazines, and a mechanism has been proposed for the reaction (614). For example, the reaction of potassium with methylpyrazine and ethyl methyl ketone, catalyzed by sodamide (0.25 mol) gave 88% of 2 -butyl-6-methylpyrazine. [Pg.74]

See other pages where 2-Acetonyl-6-phenylpyrazine is mentioned: [Pg.81]    [Pg.81]    [Pg.352]    [Pg.81]    [Pg.300]    [Pg.81]    [Pg.352]    [Pg.352]   
See also in sourсe #XX -- [ Pg.81 ]

See also in sourсe #XX -- [ Pg.81 ]



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2-Phenylpyrazine

Acetonylation

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