Acetonitrile oxide, building block

The Cp Ru(ii) fragment, easily available as the tris(acetonitrile) complex salt [Cp Ru(NCMe)3]CF3S03, has been reported as a very well suited building block for the formation of cationic mixed Cp -arene donor systems [73], This constitutes an alternative to ruthenocene derivatives that do not afford the corresponding ruthenocenium salts on oxidation, but usually readily decompose [74]. Since the Cp Ru(ii) fragment has a high affinity for arenes, a number of mono-, di-, and... 

Several possibilities for a large-scale synthesis of mesitylacetic acid 12, a central building block in the synthesis of spiromesifen 8a, were examined (Scheme 28.4.2). Using the classical standard route, mesitylene 13 is transferred into mesityl acetonitrile 14 via chloromethylation and cyanide exchange, which is then saponified to the aryl acetic acid. Another route examined is the Friedel-Crafts alkylation of mesitylene with 1,3-dichloro-propene to the adduct 15, which is ozo-nolyzed to the corresponding aldehyde in the form of its dimethyl acetal and than further oxidized with hydrogen peroxide under acidic conditions to mesityl acetic... 

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