Acetone oxime Beckmann rearrangement

The photochemically induced oxidation of the isoxazolidines (220), (221), and (222) has been investigated.Typically, the major product from the photolysis of (220) in acetone was the nitro-compound (223), whereas in benzene it was the dimer (224). In an attempt to establish the general mechanism, photo-Beckmann rearrangements were studied for a series of oximes. In each case a pair of... 

A silica sulphate (Si02-OSOjH)-supported Beckmann rearrangement of oximes 2 (R = R = H, alkyl, aryl and heterocyclyl) under microwave irradiation in acetone was reported by Li et This recyclable catalyst upon simple workup procedure furnished amides 3 rapidly with high selectivity. 

Phosphorous pentoxide effectively catalyzed the homogeneous liquid phase Beckmann rearrangement of cyclohexanone oxime 5 to lactam 6 in DMF. The catalytic activity was significantly increased by addition of trifluoromethanesulfonic acid as a co-catalyst. This protocol was fiuther extended to the rearrangement of acetone, acetophenone and cyclopentanone oxime to the corresponding amides. 

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