Acetogenins stereoselective synthesis

A double intramolecular Sn> O-cyclization for the stereoselective synthesis of the bistetra-hydrofuran core of Acetogenins has been achieved <99JOC2259>. 

Total Stereoselective Synthesis of Acetogenins of Annonaceae A New Class of Bioactive Polyketides... 

It is to answer so many questions that different groups around the world are studying the total stereoselective synthesis of acetogenins of Annonaceae. 

Stereoselective intramolecular oxymercuration of carbohydrate derivatives was proposed as the key reaction for efficient preparation of mono- and dihydroxylated unsymmetrical bis-tetrahydrofuran skeletons present in naturally occurring biologically active acetogenins. The trans- and. mz-selective intramolecular oxymercurations were explored in an enantioselective synthesis of the bis-tetrahydrofuran skeleton of mucoxin (Fig. 57).73... 

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