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Sterically hindered derivatives of isoxazole carboxylic acids have yielded a goodly number of antibiotics. Chlorination of the oxime of the appropriately substituted benzaldehydes (15) leads to the intermediates, ( 16. Condensation of the chloro oximes with ethyl acetoacetate in base gives the esters (17) of the desired isoxazole carboxylic acids. Alternately, the esters... [Pg.412]

See other pages where Acetoacetic acid ethyl ester, oxime is mentioned: [Pg.75] [Pg.91] [Pg.53] [Pg.55] [Pg.1172] [Pg.216] [Pg.1265]