2- acetic phenylhydrazide

The reaction of phenylhydrazine with phenylazoalkenes at low temperature yields labile 1 -phcnylhydrazino-phcnylhydrazones, which arc converted at higher temperature to the thermodynamically more stable (2-phenylhydrazino)-phcnylhydrazones.115 In the saccharide scries, treatment of 3,4,5,6-tetraacetyl-l-phenylazo-rram-l-hexenes (61) with phenylhy-drazine was shown to yield the free osazoncs (63), denoting that oxidation of the addition product (62) must have occured during the reaction. It should be noted that the ester groups are eliminated by transamidation to form acetic phenylhydrazide.132,214 Several azoalkenes and azoalkcnc in-... 

Early experiments with pyridine-2,3-dicarboxylic mono- and bis-phenylhydrazides were unsuccessful (32JIC145), but later these were cyclized in acetic acid (66CPBIOIO) to give only the 7-phenylpyrido[2,3-[Pg.242]

Cyano-3-methyl-5,6-dihydro-l//-pyrido[l,2-a]quinazoline-l,6-dione and its 5-substituted derivatives were prepared from 2-cyano-3-methylpyrido[l,2-a][3,l]benzoxazin-6-one with ammonium acetate at 200°C for 4 h, with hy-droxylamine hydrochloride and (thio)ureas in a boiling mixture of pyridine and ethanol for 4-7 h, with hydrazine hydrate, phenylhydrazide, primary aliphatic and (hetero)aromatic amines in boiling ethanol for 3-6 h (93CCC1953). 

Kelly found that active MnOj oxidizes phenylhydrazides smoothly in aqueous acetic acid at room temperature to give the corresponding acids in good yield aromatic reaction products are benzene (30%), phenol (27%), and phenyl acetate o H H... 

A freshly prepared solution of D-thiogalactonic acid phenylhydrazide gives no reaction either with sodium nitroprusside or with lead acetate, but, when allowed to stand for a considerable time, both reactions are positive, presumably in consequence of decomposition. Boiled for an hour in aqueous solution, D-thiogalactonic acid phenylhydrazide is transformed into D-galactonic phenylhydrazide. 

A soln. of N-carbobenzoxy-a-L-glutamylglycine ethyl ester y-phenylhydrazide in 60%-acetic acid treated with activated MnOg, stirred 30 min. at room temp., more MnOg added, and stirring continued for 15 min. N-carbobenzoxy-a-L-glutamylglycine ethyl ester. Y 82%.—No racemization occurs. F. e. s. R. B. Kelly, J. Org. Ghem. 28, 453 (1963). 

Acetic acid 2-phenylhydrazide, in P-00134 2-Acetyl-4-methylpyridine Oxime (E-), in... 

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