Acetaminophen bronchospasm with

Contraindications fc>r nonsalicylate NSAID therapy are the same as those for aspirin (see Box 7-I).The formation of a gastric ulcer or erosion that may bleed profusely is a serious potential problem with NSAIDs. Consequently, the nonsalicylate NSAIDs should be avoided or used with great caution in patients with active peptic ulcer disease. NSAIDs may increase the risk of GI complications even when used in conjunction with low-dose aspirin for cardioprotection. In addition, because of potential crosssensitivity to other NSAIDs, the nonsalicylate NSAIDs should not be given to patients in whom aspirin or other NSAIDs have caused symptoms of asthma, rhinitis, urticaria, angioedema, hypotension, bronchospasm, or of symptoms of hypersensitivity reactions. Opioids, tramadol, or acetaminophen may be suitable alternatives for patients with known or suspected susceptibility. 

The major acute reaction to intravenous amphotericin B is fever and chills, which typically end spontaneously in 30 minutes and often abate with subsequent infusions. Tachypnea and modest hypotension may occur, but true bronchospasm or anaphylaxis is rare. Patients with preexisting cardiac or lung disease may become hypotensive or hypoxic. Pretreatment with oral acetaminophen or intravenous glucocorticoids decreases reactions, while meperidine may shorten the duration of established reactions. 

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