Accurate mass measurement Drug screening

Hopfgartner, G. Vdbois, F. The impact of accurate mass measurements using quadrupole/time-of-flight mass spectrometry on the characterisation and screening of drug metabolites. Analusis 2000, 28, 906-914. 

Ojanperae, I., Pelander, A., Laks, S., Gergov, M., Vuori, E., and Witt, M. (2005). Application of accurate mass measurement to urine drug screening. J. Anal. Toxicol. 29 34-40. 

The use of deuterated pharmaceuticals to study intermediary drug metabolism with GC—MS analytical techniques has increased enormously in the last decade and has been discussed in a previous section. Quantitative isotope mass spectrometry may well come into its own in this field in the near future for general screening. Whilst individual metabolites cannot be monitored, the total deuterium excreted in the urine can be accurately measured and thus provide a good indication of the excretion time course of total deuterium label. 

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