Accumulation of Chemicals by SPMDs

When equilibrium is attained, the rate of nptake balances the rate of loss, and Eq. 2.1 reduces to 

This stage of the uptake process is therefore called the equilibrium sampling phase . 

The time it takes to reach 50% of the eqnilibrium concentration (0/a) is related to the elimination rate constant ( e) by 

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Although Theory and Modeling is more extensively discussed in Chapter 3, it is helpful to briefly discuss some basic concepts related to the accumulation of chemicals by SPMDs. Huckins et al. (1993) have shown that the uptake process obeys first-order kinetics (Figure 2.3). This type of exchange kinetics is characterized by half-lives (ti/2), which are constant for a particular set of conditions and... 

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