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Accumulation factor, multiple dosing

The progressive increase of chemical and/or metabolites in the body. Accumulation is influenced by the dosing interval and half-life of the chemical. The process can be characterized by an accumulation factor, which is the ratio of the plasma concentration at steady state to that following the first dose in a multiple dosing regimen. [Pg.694]

The right-hand side of Equation 1.30 also equals the accumulation factor, which is the factor by which accumulation occurs in the body upon multiple dosing, predicting the increase in relative to This factor can also be used to establish a... [Pg.19]

See other pages where Accumulation factor, multiple dosing is mentioned: [Pg.56]    [Pg.29]    [Pg.146]    [Pg.665]    [Pg.18]    [Pg.379]    [Pg.162]    [Pg.495]    [Pg.125]    [Pg.130]    [Pg.83]    [Pg.390]    [Pg.2285]    [Pg.3888]    [Pg.606]   
See also in sourсe #XX -- [ Pg.19 ]



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Accumulated dose

Accumulation factor

Multiple dose

Multiple dosing

Multiple dosing accumulation

Multiple factors

Multiplicity factor

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