Absorption optimizing control

Aqueous solubility, potency and permeability are three factors under medicinal chemistry control that must be optimized to achieve a compound with acceptable oral absorption. Typically, a lead (chemistry starting point) is deficient in all three parameters. The inter-relationships of these three parameters has been described in a series of publications from Pfizer researchers [7, 8]. Figure 9.1 depicts graphically the minimum acceptable solubility as a function of projected clinical potency and intestinal permeability. A minimum thermodynamic aqueous solubility of 52... 

Borchardt, R. T., Optimizing oral absorption of peptides using prodrug strategies, J. Controlled Release 1999,... 

Name five instrument controls that must be optimized when setting up an atomic absorption spectrophotometer for measurement. Explain why each must be optimized. 

Ando, T., Urakami, T., Itoh, H., and Tsuchiya, Y. 2002. Optimization of resonant two-photon absorption with adaptive quantum control. Appl. Phys. Lett. 80 4265-67. 

We have thus identified a mechanistic picture of the IC dynamics and their control that allows attribution of the measured optimal modulation to a specific mode. However, the mechanism is based on the assumption that IRS is relevant in carotenoids. In the following experiment we strive to directly detect that assumed hot ground state by the corresponding redshifted ground-state Car So-S2 absorption. 

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