Absorption, 6-8 drug classification

A biopharmaceutics drug classification scheme (BDCS) for correlating in vitro drug product dissolution and in vivo bioavailabUity is based on recognizing that drug dissolution and GI permeability are the fundamental parameters controlling the rate and extent of drug absorption. The BDCS is defined as ... 

Deconinck, E Hancock, T Coomans, D., Massart, D. L, Vander Heyden, Y. Classification of drugs in absorption classes using the classification and regression trees (CART) methodology. 

Bergstrom, C. A. S., Strafford, M., Lazarova, L., Avdeef A., Luthman, K., Artursson, P. Absorption classification of oral drugs based on molecular surface properties. /. Med. Chem, 2003, 46, 558-570. 

Fig. 12 Illustration of the Biopharmaceutical Classification System (BCS), which classifies drug absorption potential on the basis of aqueous solubility or membrane permeability. (Copyright 2000 Saguaro Technical Press, Inc., used with permission.)...

Fig. 7.5. The Biopharmaceutics Classification System (BCS) provides a scientific basis for predicting intestinal drug absorption and for identifying the rate-limiting step based on primary biopharmaceutical properties such as solubility and effective intestinal permeability (Pefr). BCS serves as a product control instrument. The BCS divides drugs into four different classes based on their solubility and...

Table 2 Rate-Limiting Step to Absorption and Requirements for Dissolution According to BCS Classification of the Drug Substance...

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