Abnormal spermatozoa

Chowdhury et al. (1986) reported that occupational exposure of 10 men to lead caused a significant decrease in sperm count and motility and an increased percentage of abnormal spermatozoa. The average PbB concentration in the lead-exposed group was higher (42.5 pg/dL) compared to controls (14.8 pg/dL). Assennato et al. (1987) reported decreased sperm production in 39 battery factory workers with high PbB levels ranging from 50 to 61 pg/dL, compared to 39 nonexposed workers. Lerda (1992)... 

A high percentage (up to 79%) of abnormal spermatozoa in bull ejaculates was reported as early as two weeks following oral administration of 10 doses of 4 mg/kg 1,2-dibromoethane on alternate days (Amir and Ben-David 1973). 

Testicular atrophy was seen in rats and mice with chronic gavage administration of 41 or 107mg/kg day, respectively. Abnormal spermatozoa and decreased spermatozoic concentration occurred in bulls fed EDB. ... 

In several instances severe bone marrow depression occurred, characterized by neutropenia and thrombocytopenia. The clinical chemistry profile of these cases revealed hypocholesterolemia, hyperuricemia, and hypoproteinemia. In a few cases, slight disturbance of liver function was found with mild elevations of aminotransferases. In male subjects, azoospermia or abnormal spermatozoa and reduced motility of spermatozoa were observed. Some cases presented with postexposure lacrimation, hyperemia, and edema of the conjunctiva. There were instances of protracted reduction in visual capacity and reports of retinal abnormalities [45]. Lymphocytes from exposed subjects showed a considerable number of chromosomal aberrations [46,47]. 

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