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ABCG2 gene

P.L.R. Ee, X. He, D.D. Ross, and W.T. Beck. Modulation of breast cancer resistance protein (BCRP/ABCG2) gene expression using RNA interference. Mol Cancer Ther. 3 1577-1584 (2004). [Pg.395]

Robey, R. W., Honjo, Y., Morisaki, K., et al. (2003) Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity. Br. J. Cancer 89, 1971-1978. [Pg.59]

In AML cells, ABCG2 is overexpressed however, the association between the expression and clinical resistance to anticancer drugs remains undetermined (81,82). The identification of functional sequence variation in the ABCG2 gene could also be of interest in the field of prognosis of disease. [Pg.71]

Ee, P.L.R., Kamalakaran, S., Tonetti, D., He, X., Ross, D.D., and Beck, W.T. (2004) Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene. [Pg.261]

For other efflux transporters such as BCRP (ABCG2), human pharmacokinetic and pharmacodynamic data are currently rare. However, an investigation of the influence of polymorphisms in ABC-transporter genes on the accumulation of nelfinavir in peripheral blood mononuclear cells (PBMCs) revealed no associations between the polymorphisms in the transporters analyzed and the accumulation of nelfinavir in the PBMCs [151], A second study in patients clearly demonstrated an increase in the AUC of the orally and intravenously administered BCRP substrate topotecan when it is given with GF120918, an inhibitor of P-glycoprotein and BCRP [152],... [Pg.352]

Table 4.2 Primers used to amplify selected polymorphisms in the ABCBl, ABCG2, OATPIBI, and OATP1B3 genes... [Pg.48]

Kobayashi, D., leiri, I., Hirota, T., et al. (2005) Eunctional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta. Drug Metab. Dispos. 33, 94-101. [Pg.59]

Backstrom, G., Taipalensuu, J., Melhus, H., et al. (2003) Genetic variation in the ATP-binding Cassette Transporter gene ABCG2 (BCRP) in a Swedish population. Eur. J. Pharm. Sci. 18, 359-364. [Pg.76]

Lapatinib had been shown ex vivo to be primarily metabolized by CYP3A4/5 with a minor contribution from CYP2C19, and to be a substrate of the transporters MDRl(ABCBl) and BCRP(ABCG2). A hypothesis was proposed whereby polymorphisms in these genes would be associated with a propensity to develop rash and/or diarrhea. [Pg.317]

Y., Irie, S., Ware, J., Nakai, Y., Higuchi, S. and Sugiyama, Y. (2008) Pharmacogenetic characterization of sulfasalazine disposition based on NAT2 and ABCG2 BCRP) gene polymorphisms in humans. Clinical Pharmacology and Therapeutics 84, 95-103. [Pg.325]


See other pages where ABCG2 gene is mentioned: [Pg.70]    [Pg.76]    [Pg.220]    [Pg.365]    [Pg.501]    [Pg.304]    [Pg.334]    [Pg.70]    [Pg.76]    [Pg.220]    [Pg.365]    [Pg.501]    [Pg.304]    [Pg.334]    [Pg.267]    [Pg.267]    [Pg.297]    [Pg.225]    [Pg.401]    [Pg.568]    [Pg.42]    [Pg.46]    [Pg.53]    [Pg.360]    [Pg.97]    [Pg.317]    [Pg.91]    [Pg.179]    [Pg.471]    [Pg.255]    [Pg.679]    [Pg.217]    [Pg.218]    [Pg.219]    [Pg.77]    [Pg.92]    [Pg.98]    [Pg.107]    [Pg.112]    [Pg.487]    [Pg.441]    [Pg.394]   
See also in sourсe #XX -- [ Pg.365 ]




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ABCG2

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