ABCC transporters

Interestingly, these assays have been employed to address the functional consequences of polymorphisms in the ABCC family of transporters but no notable alterations in transport capacity have been found (43). It seems that although ABCC transporters contain several potentially important polymorphisms and are important in drug transport overall, functional variability is actually quite low. This is perhaps the reason for the multiple negative studies that have assessed ABCC polymorphisms as they relate to drug bioavailability (20). 

Bronger, H., Konig, J., Kopplow, K., Steiner, H.H., Ahmadi, R., Herold-Mende, C., Keppler, D. and Nies, A.T. (2005) ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier. Cancer Research, 65, 11419-11428. 

Klein M, Burla B, Martinoia E. 2006. The multidrug resistance-associated protein (MRP/ABCC) subfamily of ATP-binding cassette transporters in plants. FEBS Lett 580 1112-1122. 

Bronger H, Konig J, Kopplow K, et al. ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier. Cancer Res 2005 65 11419-11428. 

Choudhuri, S., and Klaassen, C. D. Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. Int. J. Toxicol. 25, 231-259, 2006. 

Paumi, C.M., Chuk, M., Snider, J., Stagljar, I., and Michaelis, S. (2009). ABC transporters in Saccharomyces cerevisiae and their interactors new technology advances the biology of the ABCC (MRP) subfamily. Microbiol Mol Biol Rev 73 577-593. 

The ABCC family of ABC transporters includes nine drug transporters, referred to as multidrug resistance proteins (MRPs). Like Pgp and BCRP, MRPs have also demonstrated MDR to cancer cells. Nine MRP transporters have been identified. As detailed in Table 9.2,... 

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