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ABC excinuclease

Encode ABC excinuclease subunits UvrA and UvrB Encode DNA polymerase V... [Pg.977]

In E. coli, the key enzymatic complex is the ABC excinuclease, which has three subunits, UvrA... [Pg.972]

Nucleotide-excision repair is common for DNA lesions caused by ultraviolet or chemical means, which often lead to deformed DNA structures. Figure 10.16 demonstrates how a large section of DNA containing the lesion is removed by ABC excinuclease. DNA polymerase I and DNA ligase then work to fill in the gap. This type of repair is also the most common repair for ultraviolet damage in mammals. Defects in DNA repair mechanisms can have drastic consequences. One of the most remarkable examples is the disease xeroderma pigmentosum. Affected individuals develop numerous skin cancers at an early age because... [Pg.276]

See other pages where ABC excinuclease is mentioned: [Pg.967]    [Pg.972]    [Pg.973]    [Pg.251]    [Pg.281]    [Pg.967]    [Pg.973]    [Pg.977]    [Pg.496]    [Pg.496]    [Pg.497]    [Pg.278]    [Pg.278]    [Pg.70]    [Pg.967]    [Pg.972]    [Pg.973]    [Pg.251]    [Pg.281]    [Pg.967]    [Pg.973]    [Pg.977]    [Pg.496]    [Pg.496]    [Pg.497]    [Pg.278]    [Pg.278]    [Pg.70]   
See also in sourсe #XX -- [ Pg.496 ]



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ABC

Excinuclease

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