Abacavir Ethanol

Drugs that might affect amprenavir include abacavir, aldesleukin, antacids, anticonvulsants, azole antifungals, clarithromycin, cyclosporine, dexamethasone, buffered didanosine, disulfiram, ethanol, indinavir, methadone, metronidazole, nelfinavir, nonnucleoside reverse transcriptase inhibitors, oral contraceptives, rifamycins, ritonavir, saquinavir, St. John s wort, tacrolimus, and zidovudine. 

Abacavir undergoes extensive hepatic metabolism therefore, patients with liver disease should be monitored closely if this drug is given. Ethanol inhibits the metabolism of abacavir because it competes for metab-... 

There are no serious drug interactions associated with abacavir with the exception that high ethanol consumption may increase its plasma levels and affect its elimination. 

McDowell JA, Chittick GE, Stevens CP, Edwards KD, Stein DS. Hiarmacckinetic interaction of abacavir (1592U89) and ethanol in human immunodeficiency virus-infected adults. Antind-crob Agents Chemother (20 ) AA, 1686-90. 

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