A Uracil to 1,2,3-Triazole Conversion

Hydrolysis of 5-diazo-l-methyluracil-6-methanolate 1 with 5% (v/v) aqueous acetonitrile at 100°C gives l-methyl-4-carboxamido-1,2,3-triazole in 78% yield. 

In 1928, Schumm discovered that heating vinyl porphyrins in molten resorcinol resulted in facile loss of the vinyl groups from the porphyrins. It was subsequently shown that l -hydroxyalkyl, formyl and acetyl porphyrins behave similarly under the same conditions, i.e. these substituent groups also are removed. The Schumm devinylation reaction has been used in both synthetic and degradation studies on porphyrins, and it was stated in a paper in the Journal of Organic Chemistry that One of the most useful reactions in the chemistry of natural porphyrins is the devinylation of vinyl porphyrins in molten resorcinol.  

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