A-Morpholino-ketone

The formation of the amine (496) when 3)5-toluene-p-sulphonates are treated with 2-dimethylaminoethanol involves both inversion at C-3 and demethyla-tion. The reaction of androstane-16,17-ketols and 17 -acetoxy-16a,Ha-epoxide with morpholine to give a-morpholino-ketones has been thoroughly investigated and rationalised. H/5-Aminoandrosta-3,5-diene, prepared by reduction of the H-oxime, possesses some antimicrobial activity which is not enhanced by substitution of the amino-groups with 2-chloroethyl, 2-hydroxy-ethyl, or 3-aminopropyl groups similar 2-chloroethyl substituted H)5-amines have been cyclised by treatment with base to give H -aziridines. All four... 

Energy transfer is rather seldom encountered [2j] due to the obvious difficulty to have the S triplet-state level higher than that of I. The most typical case of energy transfer is encountered between a thioxanthone derivative and a morpholino ketone derivative (10.60) the excitation moves from the thioxanthone triplet state to the morpholino ketone triplet state. With other thioxanthone derivatives, electron transfer followed by proton transfer with the amine moiety can compete to some extent [212]. The sensitized cleavage in covalently linked thioxanthone derivative/cleavable photoinitiator was recently investigated and discussed [213],... 

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