A-keto amino acids

Figures Selective protein modification using a keto amino acid, p-acetyl-L-phenylalanine. (a) Labeling of fluorescein hydrazide to the Z domain protein. Only the mutant protein containing p-acetyl-L-phenylalanine was labeled and became fluorescent, (b) A general method for preparing glycoprotein mimetics with defined glycan structure.

Wittig reactions of diethyl oxalate with a variety of arylmethylene-triphenylphosphonium ylides under mild conditions provide a highly (Z)-stereoselective synthesis of ethyl 3-aryl-2-ethoxyacrylates (69). Wittig reactions of the a-keto amino acid derivative (70) with stabilized, semi-stabilized and reactive ylides have been used to prepare the synthetically... 

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