A Continuous Reaction-Limited Dissolution Model

Lansky and Weiss [122] proposed a novel model by considering the reaction of the undissolved solute with the free solvent yielding the dissolved drug complexed with solvent  

Further, global concentrations as a function of time for the reactant species of the above reaction were considered, assuming that the solvent is not in excess and applying classical chemical kinetics. The following equation was found to describe the rate of drug dissolution in terms of the fraction of drug dissolved  

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