A-bromotoluene

Preparation of Nitriles Investigated in Micro Reactors Organic synthesis 4 [OS 4] Nitrile synthesis from a-bromotoluene... 

P 3] This protocol was performed identically with [P 2], with the exception of the reactants and conditions. a-Bromotoluene was nucleophilically substituted in benzene to give a-fhiocyanotoluene at 70 °C (12 h) using rhodanide coupled to a porous polymer resin [3]. 

Azide Substitutions Investigated in Micro Reactors Organis synthesis 6 [OS 6] Azide substitution of a-bromotoluene... 

Bromothymol Blue [76-59-5] M 624.4, m 201-203 . Dissolved in aq 5% NaHCO3 soln and ppted from the hot soln by dropwise addn of aq HCI. Repeated until the extinction did not increase (Xmax 420nm). a-Bromotoluene see henzyl bromide. 

The amount of catalytically active bromide is different for each due to the variation of the concentration of a-bromotoluene during the experiments. a-Bromotoluene is an inactive form of bromine in these reactions [14]. The appropriate manner to express the yield of benzylic bromides is on the initial sodium bromide added rather than on the initial toluene basis since sodium bromide is the limiting reagent. The benzylic bromide yields, on a sodium bromide basis, range from 22% for the Mn/Br catalyst to 93 for the Co/Mn/Br catalyst, see figure 5. Thus the effective bromide concentration varies from 7 to 78%... 

Interestingly, the more active catalysts contain the highest amount of inactive bromide, i.e., the highest yield of a-bromotoluene, see figure 5 ... 

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