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A-Acetylamino-alkyl methyl ketone

The direct conversion of an a-amino acid into the corresponding a-acetylamino-alkyl methyl ketone, via oxazoline (azalactone) intermediates. The reaction proceeds in the presence of acetic anhydride and a base such as pyridine with the evolution of CO2. [Pg.179]

The general approach can be enlarged and conditions for condensation made milder by the use of further-activated esters, thus condensation with methyl nitroacetate produces 3-nitro-coumarins, condensations with Wittig ylides " allow orffto-hydroxyaryl ketones to be used ° and the use of diethyl malonate (or malonic acid ) (a 3-ester can be removed by hydrolysis and decarboxylation ), malononitrile, ethyl trifluo-roacetoacetate, or substituted acetonitriles in a Knoevenagel condensation, produces coumarins with a 3-ester, 3-trifluoroacetyl, " 3-cyano, or 3-alkyl or -aryl substituent. Condensation with IV-acetylglycine generates 3-acetylamino-coumarins. ... [Pg.239]


See other pages where A-Acetylamino-alkyl methyl ketone is mentioned: [Pg.120]    [Pg.354]    [Pg.184]    [Pg.160]   
See also in sourсe #XX -- [ Pg.179 ]

See also in sourсe #XX -- [ Pg.167 ]

See also in sourсe #XX -- [ Pg.192 ]

See also in sourсe #XX -- [ Pg.167 ]




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Acetylamino alkylation

Alkyl methyl ketones

Alkyl-methyl

Alkylated ketone

Alkylation ketone

Ketones a- alkyl

Ketones a-alkylated

Ketones a-alkylation

Ketones alkyl

Methyl ketones, alkylation

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