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9a-Fluorocortisol

The slight conformational modification of the cycle A (revealed by X-ray diffraction), which probably comes from an interaction between the fluorine at C-9 and the axial OH at C-1, could contribute to the change in affinity [131]. However X-ray structure of the fluorocortisol co-crystallised with the glucocorticoid receptor does not clearly explain the impact of fluorine on the increased affinity for the receptor (cortisol, Ki=0.67pM vs 9a-fluorocortisol K,=0.027 pM) [132,133],... [Pg.598]

Fluorocholest-4-en-3-one, 451 3/3-Fluorocholest-5-ene, 443 5a-Fluorocholestanyl acetate, 442 9a-Fluorocortisol, 433 9 -Fluorocortisol acetate, 425, 434 9a-Fluorocortisol 21-mesylate, 449... [Pg.261]

Methylated Glucocorticoids. The preparation of 2a-methyl-9a-fluorocortisol has been reported (76). This compound shows enhanced glucocorticoid activity and greatly enhanced mineralocorticoid activity, so much that it surpasses aldosterone (19) in sodium-retaining and potassium-excreting potency. Attention was then turned to the preparation of 6-methylated corticoids... [Pg.101]

See other pages where 9a-Fluorocortisol is mentioned: [Pg.287]    [Pg.424]    [Pg.425]    [Pg.433]    [Pg.434]    [Pg.444]    [Pg.449]    [Pg.261]    [Pg.221]    [Pg.226]    [Pg.231]    [Pg.482]    [Pg.486]    [Pg.494]    [Pg.269]    [Pg.101]    [Pg.646]    [Pg.511]    [Pg.331]    [Pg.258]   
See also in sourсe #XX -- [ Pg.433 ]

See also in sourсe #XX -- [ Pg.31 ]



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9a-Fluorocortisol acetate

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