5HT3 receptor antagonists granisetron

Ondansetron is one of a group of 5HT3-receptor antagonists currently available in the UK, which also includes granisetron, tropisetron, dolasetron and palonosetron. Dexamethasone is a corticosteroid. Ranitidine is a histamine-2 (H2)-receptor antagonist. 

One of the major side-effects of cytotoxic chemotherapy is nausea and vomiting. It is essential therefore to control this with prophylactic antiemetic therapy. A number of agents are currently available and are effective at controlling chemotherapy-induced emesis. The most potent of these are 5HT3-receptor antagonists that include ondansetron, granisetron and palonosetron. 

Azasetron, a potent selective 5HT3 receptor antagonist, is a benzamide derivative that has a different chemical structure and a longer duration of action than other 5HT3 receptor antagonists, such as granisetron, ondansetron, and tropisetron [29 ]. For a comparison of azasetron with ondansetron, see above. 

Ondansetron, granisetron, topisetron, and batanopride are antagonists of the 5HT3 receptor, and are considered effective in controlling cancer-chemotherapy-induced emesis. Clozapine, an effective antipsychotic agent (neuroleptics) with little or no extrapyramidal... 

HT3 (a serotonin receptor—see the following section) antagonists ondansetron, granisetron... 

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