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18F-fluorothymidine

Applying this novel fluorination method to 18F-fluorination provides great improvement in radiochemical yields (Table 14.5) [101]. The use of a protic solvent in nucleophilic 18F-fluorination not only improved the radiochemical yield of widely used radiopharmaceuticals such as [18F]FLT (3 -deoxy-3 -[18F]fluorothymidine) [101, 102], [18F]FP-CIT (3-[18F]fluoropropyl-2-(3-carboxymethoxy-3-(3-(4-iodophenyl) nortropane) [101, 103], and [18F]FMISO ([18F]fhioromisonidazole) [101, 104], which were difficult to prepare in conventional methods under mild conditions. This method has advanced the availability of these important radiopharmaceuticals, and should help the development of new pharmaceuticals for research and clinical application in the future. [Pg.382]

Describe the method of synthesis of (a) 6-18F-L-Fluorodopa (b) 18F-fluorothymidine (c) 11C-L-methionine. [Pg.148]

Smyczek-Gargya, B., Fersis, N., Dittmann, H., Vogel, U., Reischl, G., Machulla, H.J., et al. PET with [18F]fluorothymidine for imaging of primary hreast cancer a pilot study. European Journal of Nuclear Medicine and Molecular Imaging 31(5), 720-724 (2004)... [Pg.403]

Herrmann, K., Wieder, H.A., Buck, A.K., Schoffel, M., Krause, B.J., Eend, E., et al. Early response assessment using 3 -deoxy-3 -[18F]fluorothymidine-positron emission tomography in high-grade non-Hodgkin s lymphoma. Climcal Cancer Research an Official Journal of the American Association for Cancer Research. 13(12), 3552-3558... [Pg.403]

See other pages where 18F-fluorothymidine is mentioned: [Pg.52]    [Pg.388]    [Pg.167]    [Pg.52]    [Pg.388]    [Pg.167]   
See also in sourсe #XX -- [ Pg.134 ]



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