18F-fluoromisonidazole

F-fluoromisonidazole [81] in hypoxic tissue have led to the development of such an agent based on 99mTc, All of these studies to date have involved the incorporation of the 2-nitroimidazole function onto a known stable complex for technetium. 

PET imaging using 8F-fluoromisonidazole (FMISO) and 18F-fluoroazomycinarabinofuranoside (FAZA) is well established for human application, allowing the measurement of hypoxia status. Their limitations include poor availability of the radiolabeled product and short lifetime of the 18F PET isotope (half life ca. 110 min). 

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