17a-hydroxylase 17,20-LYASE

Akhtar M, DL Corina, SL Miller, AZ Shyadehi (1994) Incorporation of label from into acetate during side-chain cleavage catalyzed by cytochrome P-450j7 (17a-hydroxylase-17,20-lyase). J Chem Soc Perkin Trans T. 263-267. [Pg.135]

Fig. 9.5 Structural formula of the 17a-hydroxylase-17,20-lyase inhibitor MH61.

The Sex Steroid Pathway Is Initiated by 17a-Hydroxylase/17,20-Lyase (CYP17)... [Pg.706]

Corina, D.L., S.L. Miller, J.N. Wright, and M. Akhtar (1991). The mechanism of cytochrome P-450 dependent carbon-carbon bond cleavage Studies on 17a-hydroxylase-17,20-lyase. Chem. Commun. 782-783. [Pg.241]

Lee-Robichaud, R, M.E. Akhtar, and M. Akhtar (1998). An analysis of the role of active site protic residues of cytochrome P-450s Mechanistic and mutational studies on 17a-hydroxylase-17,20-lyase (P-45017a also CYP17). Biochem. J. 330, 967-974. [Pg.241]

Lee-Robichaud, R, A.Z. Shyadehi, J.N. Wright, M. Akhtar, and M. Akhtar (1995). Mechanistic kinship between hydroxylation and desaturation reactions Acyl-carbon bond cleavage promoted by pig and human CYP17 (P-45017a 17a-hydroxylase-17,20-lyase). Biochemistry 34, 14104-14113. [Pg.241]

Chung, B., J. Picado-Leonard, M. Haniu, M. Bienkowski, RE Hall, J.E. Shively etal. (1987). Cytochrome P450c 17 (steroid 17a-hydroxylase/17, 20 lyase) Cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues. Proc. Natl. Acad. Sci. USA 84,407-411. [Pg.517]

Imai, X, H. Globerman, J.M. Gertner, N. Kagawa, and M.R. Waterman (1993). Expression and purification of functional human 17a-hydroxy-lase/17,20-lyase (P450cl7) in Escherichia coli. Use of this system for study of a novel form of combined 17a-hydroxylase/17,20-lyase deficiency. J Biol. Chem. 268, 19681-19689. [Pg.518]

P. Ferreira, E.R. Simpson, and J.S. Winter (1989). Identification of a common molecular basis for combined 17a-hydroxylase/17,20-lyase deficiency in two Mennonite families. Hum. Genet. 82, 285-286. [Pg.518]

Combined 17a-hydroxylase/17,20-lyase deficiency caused by Phe93Cys mutation in the CYP17 gene. J. Clin. Endocrinol. Metab. 87, 898-905. [Pg.519]

A second enzyme system targeted for androgen inhibition is 17a-hydroxylase/17,20-lyase, which is the key enzyme that converts pregnenolone to DHAand, subsequently, to testosterone (Fig. 45.3). Because testosterone has androgenic activity, inhibition of its biosynthesis would be useful in treating androgen-dependent diseases, such as prostate cancer (130). Inhibitors of 17o-hydroxylase/17,20-lyase inhibitors could prevent androgen biosynthesis from both testes and adrenals and may provide effective treatment of patients with prostate cancer. [Pg.2035]

Akhtar M, Wright JN, Lee-RobichaudP (2011) A review of mechanistic studies on aromatase (CYP19) and 17a-hydroxylase-17,20-lyase (CYP17). J Steroid Biochem Mol Biol 125 2-12... [Pg.175]

Hu Q, Negri M, Jahn-Hoffmann K, Zhuang Y, Ol-gen S, Bartels M, Muller-Vieira U, Lauterbach T, Hartmann RW (2008) Synthesis, biological evaluation, and molecular modeling studies of methy- 2046. lene imidazole substituted biaryls as inhibitors of human 17a-hydroxylase-17,20-lyase (CYP17)—... [Pg.755]

Swart AC, Storbeck KH, Swart P (2010) A single amino acid residue, Ala 105, confers 16a-hydroxylase activity to human cytochrome P450 17a-hydroxylase/17,20 lyase. J Steroid Biochem Mol Biol 119 112-120... [Pg.760]

Biason-Eauber A, Kempken B, Werder E, Forest MG, Einaudi S, Ranke MB, Matsuo N, 2179. Brunelli V, Schonle EJ, Zachmann M (2000) 17a-Hydroxylase/17,20-lyase deficiency as a model to... [Pg.761]

Mathieu AP, Auchus RJ, LeHoux JG (2002) Comparison of the hamster and human adrenal P450cl7 (17a-hydroxylase/17,20-lyase) using site-directed mutagenesis and molecular modeling. J Steroid 2204. Biochem Mol Biol 80 99-107... [Pg.762]

Auchus RJ, Miller WL (1999) Molecular modeling of human P450cl7 (17a-hydroxylase/17,20-lyase) insights into reaction mechanisms and ef- 2208. fects of mutations. Mol Endocrinol 13 1169-1182... [Pg.762]

Schappach A, Holtje HD (2001) Molecular modelling of 17a-hydroxylase-17,20-lyase. Pharmazie 56 435-442... [Pg.762]

Owen CP (2009) 17a-Hydroxylase/17,20-lyase (P450( 17a)) inhibitors in the treatment of prostate 2230. cancer a review. Anticancer Agents Med Chem 9 613-626... [Pg.763]

Lee-Robichaud P, Wright JN, Akhtar ME, Akhtar M (1995) Modulation of the activity of human 17a-hydroxylase-17,20-lyase (CYP17) by cyto-ehrome b. endocrinological and mechanistic implications. Biochem J 308 901-908... [Pg.875]

Picado-Leonard J, Miller WL (1987) Cloning and sequence of the human gene encoding P450cl7 (steroid 17a-hydroxylase/17,20 lyase) similarity to the gene for P450c21. DNA 6 439 8... [Pg.876]

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