Gymnomitrol


Jptt Piit. 48 50998 (fuly 18, 1973), Kanamasa, M. Takeo, and S. Hiroshi (to Gentral Glass Go., Ltd.).  [c.181]

Adrenergic Neuronal Blockers. The adrenergic neuronal blocking agents, guanethidine, bretjlium, debrisoquin, and guanadrel (Table 6), produce hypotension by blocking the release of norepinephrine from the nerve terminals of adrenergic neurons. These dmgs are taken up by the neurons and decrease sympathetic tone, heart rate, cardiac output, and total peripheral resistance. Some deplete norepinephrine stores and thus produce an initial sympathornimetic response increasing these various responses. Orthostatic hypotension, severe sexual dysfunction and impairment, fluid retention, and diarrhea are the primary side effects of this class of agents which is obsolete and used only when no other agents work.  [c.141]

The guanidine function has proven particularly useful in providing antihypertensives that act by peripheral sympathetic blockade. Several such compounds that contain a quite different hydrocarbon moiety are met later (guanadrel, guanethidine, guan-cycline, debrisoquin). Reaction of benzylamine with methyl isothiocyanate gives the corresponding thiourea (79). Methylation affords the product of alkylation at the most nucleophilic center, the thioenol ether (80). Displacement of the thiomethyl group by methylamlne (probably by an addition elimination process) affords bethanidine (81).  [c.55]

The lack of structural specificity within the sympathetic blocking agents is particularly well illustrated by a drug that is based on a heterocycle in only the loosest sense. Ketaliza-tion of cyclohexanone with l-chloro-2,3-propanediol affords 192. Displacement of halogen by means of the sodium salt of phthali-mide leads to the intermediate, 193 removal of the phthaloyl protecting group by treatment with hydrazine leads to the primary amine (194). This amine gives the hypotensive agent guanadrel (195) on reaction with the S-methyl ether of thiourea. Like all other hypotensive agents containing the guanidine function, this agent acts by blockade of the sympathetic nervous system.  [c.282]

Standards and Test Methods of the Air Movement and Gontrol Association International, Inc., 30 West University Drive Arlington Heights, Illinois 60004-1893 USA FAX 847-253-0088 Phone 847-394-0150.  [c.578]

Tobin, J. E, What Fan Gontrol Method is Best Power Eng., p. 82, Sept. (1954).  [c.578]


See pages that mention the term Gymnomitrol : [c.724]    [c.724]    [c.456]    [c.132]    [c.135]    [c.378]    [c.438]    [c.269]    [c.239]    [c.743]    [c.743]    [c.1631]    [c.1673]    [c.1706]    [c.1707]    [c.130]   
The logic of chemical synthesis (1989) -- [ c.378 ]