Alder rule chiral


The first computer simulations of fluids were performed in 1952 by Metropolis, Rosenbluth, Knsenbluth, Teller and Teller, who developed a scheme for sampling from the Boltzmann distribution to give ensemble averages. This gave rise to the Monte Carlo simulation method. Not long afterwards (in 1957) Alder recognised that it was, in fact, possible tc integrate the equations of motion for a relatively small number of particles, and to mimic tbe behaviour of a real system using periodic boundary conditions. This led to the first molecular dynamics simulations of molecular systems.  [c.319]

Diels-Alder reactions Neutral ionic liquids have been found to be excellent solvents for the Diels-Alder reaction. The first example of a Diels-Alder reaction in an ionic liquid was the reaction of methyl acrylate with cyclopentadiene in [EtNH3][N03] [40], in which significant rate enhancement was observed. Howarth et al. investigated the role of chiral imidazolium chloride and trifluoroacetate salts (dissolved in dichloromethane) in the Diels-Alder reactions between cyclopentadiene and either crotonaldehyde or methacroline [41]. It should be noted that this paper describes one of the first examples of a chiral cationic ionic liquid being used in synthesis (Scheme 5.1-17). The enantioselectivity was found to be < 5 % in this reaction for both the endo (10 %) and the exo (90 %) isomers.  [c.182]


See pages that mention the term Alder rule chiral : [c.2368]    [c.242]    [c.265]   
Advanced organic chemistry Ч.1 (2000) -- [ c.82 ]