Benzoic acidf HNOa -30 144 85-0 0-6  [c.178]

The command augtf augments the plant with the weighting functions as shown in Figure 9.31. The branch command recovers the matrices ap, bp, cp and dp packed in TSS. The hinfopt command produces the following output in the command window  [c.416]

Depletion of ATP in the cells prevents maintenance of the membrane potential, inhibits the functioning of ion pumps, and attenuates cellular signal transduction (e.g., formation of second messengers such as inositol phos phates or cyclic AMP). A marked ATP depletion ultimately impairs the activ-itv of the cell and leads to ceil death.  [c.283]

D similarity methods such as these provide the means to generate a structural alignment < molecules based upon some suitable property (electrostatics or shape). Methods such pharmacophore mapping also provide a mechanism to align molecules, but in this car based upon their pharmacophore features. A structural alignment of a set of activ molecules can be very useful in drug design, particularly when the structure of the targ< receptor is. Some of the varied techniques, such as 3D database searching and comparativ molecular field analysis, which make use of structural alignments, are discussed in th chapter. The abundance of techniques for generating such alignments reflects the comple nature of the problem, in part a consequence of the need to consider the conforniatiom flexibility of the molecules together with their relative orientations in space [Lemmen an Lengauer 2000].  [c.695]

Dunn W J III, S Wold, U Edlund, S Hellberg and J Gasteiger 1984. Multivariate Structure-Activib Relationships Between Data from a Battery of Biological Tests and an Ensemble of Structur Descriptors The PLS Method. Quantitative Structure-Activity Relationships 3 131-137.  [c.737]

Pastor M, G Cruciani and S dementi 1997. Smart Region Definition A New Way to Improve tl Predictive Ability and Interpretability of Three-Dimensional Quantitative Structure-Activi Relationships. Journal of Medicinal Chemistry 40 1455-1464.  [c.741]

By successively adding ammo acid residues to the C terminal ammo acid it took Memfield only eight days to synthesize bradykmm m 68% yield The biological activ ity of synthetic bradykmm was identical with that of natural material  [c.1142]

Protein tertiary structure is also influenced by the environment In water a globu lar protein usually adopts a shape that places its hydrophobic groups toward the interior with Its polar groups on the surface where they are solvated by water molecules About 65% of the mass of most cells is water and the proteins present m cells are said to be m their native state—the tertiary structure m which they express their biological activ ity When the tertiary structure of a protein is disrupted by adding substances that cause the protein chain to unfold the protein becomes denatured and loses most if not all of Its activity Evidence that supports the view that the tertiary structure is dictated by the primary structure includes experiments m which proteins are denatured and allowed to stand whereupon they are observed to spontaneously readopt their native state confer matron with full recovery of biological activity  [c.1146]

Short-range order parameter a Standard enthalpy of activa- m  [c.107]

Once again, to find the [Cd +] we must account for the presence of NH3 thus [Cd +] = actf+ X Ccd = (0.0881)(1.93 X 1Q- M) = 1.70 X IQ-io M giving pCd as 9.77.  [c.319]

Activa ting substituents ia one of the rings of naphthalene promote substitution ia that ring. Deactivating substituents deactivate the ring to which they are attached and electrophilic substitution occurs ia the other ring. These effects may be explained by similar arguments to those for benzene substitution patterns and many analogies may be drawn between the two systems.  [c.287]

Electrochemistry" in ECT 1st ed., Vol. 5, pp. 495—549, by G. C. Akedof, Mellon Institute of Industrial Research in ECT 2nd ed., Vol 7, pp. 784—841, by G. C. Akedof, Princeton University "Introduction" under "Electrochemical Processing" in ECT 3rd ed., Vol. 8, pp. 662—671, by P. M. Robertson, Eidgenitssiche Technische Hochschule.  [c.67]

Benzoyl-2,3-dihydro-lH-pyrrolizine-l-cai boxylic acid (ketorolac, L ) and 2-(3-benzoyl-phenyl)propionic acid (ketoprofen, L ) ai e biologically activ ligands used in medicine as non-steroidal anti-inflammatory dmgs.  [c.394]

Alumina Number 1076, aktiv basisch, for chromatography (E. Merck, Darmstadt) was usually employed. Occasionally, when alumina Number 1077, aktiv neutral, from the same company, was used, a longer reaction time was required (compare Note 15).  [c.99]

Low surface energy substrates, such as polyethylene or polypropylene, are generally difficult to bond with adhesives. However, cyanoacrylate-based adhesives can be effectively utilized to bond polyolefins with the use of the proper primer/activa-tor on the surface. Primer materials include tertiary aliphatic and aromatic amines, trialkyl ammonium carboxylate salts, tetraalkyl ammonium salts, phosphines, and organometallic compounds, which are initiators for alkyl cyanoacrylate polymerization [33-36]. The primer is applied as a dilute solution to the polyolefin surface, solvent is allowed to evaporate, and the specimens are assembled with a small amount of the adhesive. With the use of primers, adhesive strength can be so strong that substrate failure occurs during the course of the shear tests, as shown in Fig. 11.  [c.862]

S. J. Weiner, P. A. KLillman, D. A. Case, U. Chandra Singh, C. Ghio, G. Alagona, S. Profeta, P. A. Weiner. A new force field for molecular mechanical simulation of nucleic acids and proteins. J Am Chem Soe 706 765-784, 1984. D. Shechtman, I. Blech, D. Gratias, J. W. Cahn. Phys Rev Lett 52 1951, 1984. V. E. Dmitrienko, S. B. Astaf ev. Phys Rev Lett 75 1538-1541, 1995.  [c.923]

See pages that mention the term Augtf : [c.280]    [c.64]    [c.496]    [c.710]    [c.280]    [c.69]    [c.177]    [c.137]    [c.340]    [c.88]    [c.107]    [c.455]    [c.171]    [c.63]    [c.259]    [c.259]    [c.16]    [c.17]    [c.18]    [c.41]    [c.86]    [c.95]    [c.537]    [c.2534]    [c.118]    [c.283]    [c.340]    [c.415]    [c.231]    [c.257]    [c.257]    [c.739]    [c.295]   
Advanced control engineering (2001) -- [ c.416 ]